Ontology highlight
ABSTRACT:
SUBMITTER: Shen CH
PROVIDER: S-EPMC5014622 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Shen Che-Hung CH Kim Sun Hye SH Trousil Sebastian S Frederick Dennie T DT Piris Adriano A Yuan Ping P Cai Li L Gu Lei L Li Man M Lee Jung Hyun JH Mitra Devarati D Fisher David E DE Sullivan Ryan J RJ Flaherty Keith T KT Zheng Bin B
Nature medicine 20160808 9
The protein kinase B-Raf proto-oncogene, serine/threonine kinase (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BRAF (BRAFi) have shown high response rates and extended survival in patients with melanoma who bear tumors that express mutations encoding BRAF proteins mutant at Val600, but a vast majority of these patients develop drug resistance. Here we show that loss of stromal antigen 2 (STAG2) or STAG3, which encode subunits of the cohesin complex, in melanoma ...[more]