Association of prenatal antibiotics with foetal size and cord blood leptin and adiponectin.

ABSTRACT:

Background

Early postnatal antibiotic use has been shown to promote excess weight gain, but it is unclear whether intrauterine exposure to antibiotics is associated with foetal growth and adiposity. The objective of this study was to examine associations of antibiotic prescription in each trimester of pregnancy with foetal size and adipokine levels at birth.

Methods

In 2128 pregnant women from the pre-birth Project Viva cohort, from electronic medical records, we estimated antibiotic prescribing by timing during pregnancy. Outcomes were sex-specific birth weight-for-gestational-age z-score (BW/GA-z) and levels of umbilical cord leptin and adiponectin. We used linear regression models adjusted for maternal age, pre-pregnancy body mass index, parity, race/ethnicity, education,

SUBMITTER: Mueller NT 

PROVIDER: S-EPMC5014721 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature