Circulating plant miRNAs can regulate human gene expression in vitro.
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ABSTRACT:
SUBMITTER: Pastrello C
PROVIDER: S-EPMC5015063 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Circulating plant miRNAs can regulate human gene expression in vitro.
Pastrello Chiara C Tsay Mike M McQuaid Rosanne R Abovsky Mark M Pasini Elisa E Shirdel Elize E Angeli Marc M Tokar Tomas T Jamnik Joseph J Kotlyar Max M Jurisicova Andrea A Kotsopoulos Joanne J El-Sohemy Ahmed A Jurisica Igor I
Scientific reports 20160908
While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microRNAs in human blood in a large nutrigenomics study cohort and in a randomized dose-controlled trial, finding a significant positive correlation between the daily amount of broccoli c ...[more]
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