Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation.

ABSTRACT: The effect of air pollution exposure on atherosclerosis severity or incident clinical events in patients with coronary artery disease is not known. We conducted a prospective longitudinal cohort study of 6575 Ohio residents undergoing elective diagnostic coronary angiography. Multinomial regression and Cox proportional hazards models were used to assess the relationship between exposure to fine particulate matter <2.5 μm in diameter (PM2.5) and nitrogen dioxide on coronary artery disease severity at baseline and risk of myocardial infarction, stroke, or all-cause mortality over 3 years of follow-up. Among participants with coronary artery disease, exposure to PM2.5 levels was associated with increased likelihood of having coronary atherosclerosis that was mild (odds ratio 1.43, 95% CI 1.11

SUBMITTER: Hartiala J 

PROVIDER: S-EPMC5015312 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature