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F18-FDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis.

ABSTRACT: Positron emission tomography (PET) with fluor-18-deoxy-glucose (FDG) is widely used for diagnosing recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC).To assess the diagnostic accuracy of FDG-PET for DTC in patients after ablative therapy.A systematic search was conducted in Medline/PubMed, EMBASE, Cochrane Library, Web of Science, and Open Grey looking for all English-language original articles on the performance of FDG-PET in series of at least 20 patients with DTC having undergone ablative therapy including total thyroidectomy. Diagnostic performance measures were pooled using Reitsma's bivariate model.Thirty-four publications between 1996 and 2014 met the inclusion criteria. Pooled sensitivity and specificity were 79.4% (95% confidence interval [CI], 73.9-84.1) and 79.4% (95% CI, 71.2-85.4), respectively, with an area under the curve of 0.858.F18-FDG-PET is a useful method for detecting recurrent DTC in patients having undergone ablative therapy.

SUBMITTER: Haslerud T 

PROVIDER: S-EPMC5015757 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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F18-FDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis.

Haslerud Torjan T   Brauckhoff Katrin K   Reisæter Lars L   Küfner Lein Regina R   Heinecke Achim A   Varhaug Jan Erik JE   Biermann Martin M  

Acta radiologica (Stockholm, Sweden : 1987) 20150709 10

<h4>Background</h4>Positron emission tomography (PET) with fluor-18-deoxy-glucose (FDG) is widely used for diagnosing recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC).<h4>Purpose</h4>To assess the diagnostic accuracy of FDG-PET for DTC in patients after ablative therapy.<h4>Material and methods</h4>A systematic search was conducted in Medline/PubMed, EMBASE, Cochrane Library, Web of Science, and Open Grey looking for all English-language original articles on t  ...[more]

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