Ontology highlight
ABSTRACT:
SUBMITTER: Santos R
PROVIDER: S-EPMC5016002 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Santos Rosaysela R Kawauchi Shimako S Jacobs Russell E RE Lopez-Burks Martha E ME Choi Hojae H Wikenheiser Jamie J Hallgrimsson Benedikt B Jamniczky Heather A HA Fraser Scott E SE Lander Arthur D AD Calof Anne L AL
PLoS biology 20160908 9
Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here, we use a conditional/invertible genetic strategy to identify the cell lineage(s) responsible for the development of heart defects in a Nipbl-deficient mouse model of Cornelia de Lange Syndrome, in which global yet subtle transcriptional dysregulatio ...[more]