Ontology highlight
ABSTRACT:
SUBMITTER: Cohen NR
PROVIDER: S-EPMC5016029 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cell host & microbe 20111101 5
iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain bacterial and parasitic lipids and drive iNKT cell responses. How iNKT cells respond to fungi, however, is unknown. We found that CD1d-deficient mice, which lack iNKT cells, poorly control infection with the fungal pathogen Aspergillus fumigatus. Furthermore, A. fumigatus rapidly activates iNKT cells in vivo and in vitr ...[more]