Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.
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ABSTRACT:
SUBMITTER: Gamboa A
PROVIDER: S-EPMC5016238 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
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Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.
Gamboa Alfredo A Figueroa Rocío R Paranjape Sachin Y SY Farley Ginnie G Diedrich Andre A Biaggioni Italo I
Hypertension (Dallas, Tex. : 1979) 20160815 4
Impaired nitric oxide (NO) vasodilation (endothelial dysfunction) is associated with obesity and thought to be a factor in the development of hypertension. We previously found that NO synthesis inhibition had similar pressor effects in obese hypertensives compared with healthy control during autonomic blockade, suggesting that impaired NO vasodilation is secondary to sympathetic activation. We tested this hypothesis by determining the effect of autonomic blockade (trimethaphan 4 mg/min IV) on NO ...[more]
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