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Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells.

ABSTRACT: The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T cell therapeutics with a focus on how the manufacturing strategies have been refined, and where the research is heading.

SUBMITTER: Cruz CR 

PROVIDER: S-EPMC5016253 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells.

Cruz Conrad R Y CR   Bollard Catherine M CM  

Current drug targets 20170101 3

The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T cell therapeutics with a focus on how the manufacturing strategies have been refined, and where the research is heading. ...[more]

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