Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya D
PROVIDER: S-EPMC5016522 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Bhattacharyya Debmalya D Mirihana Arachchilage Gayan G Basu Soumitra S
Frontiers in chemistry 20160909
This review is focused on the structural and physicochemical aspects of metal cation coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G-quadruplex structures are non-canonical secondary structures formed by both DNA and RNA. G-quadruplexes regulate a wide range of important biochemical processes. Besides the sequence requirements, the coordination of monovalent cations in the GQ is essential for its formation and determines the stability and polymorphism of ...[more]