Identifying and Visualizing Macromolecular Flexibility in Structural Biology.

ABSTRACT: Structural biology comprises a variety of tools to obtain atomic resolution data for the investigation of macromolecules. Conventional structural methodologies including crystallography, NMR and electron microscopy often do not provide sufficient details concerning flexibility and dynamics, even though these aspects are critical for the physiological functions of the systems under investigation. However, the increasing complexity of the molecules studied by structural biology (including large macromolecular assemblies, integral membrane proteins, intrinsically disordered systems, and folding intermediates) continuously demands in-depth analyses of the roles of flexibility and conformational specificity involved in interactions with ligands and inhibitors. The intrinsic difficulties in capt

SUBMITTER: Palamini M 

PROVIDER: S-EPMC5016524 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature