Pulse pressure variation shows a direct linear correlation with tidal volume in anesthetized healthy patients.

ABSTRACT: The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation.Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision.The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r?=?0.97, P?

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5017055 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature