Ontology highlight
ABSTRACT:
SUBMITTER: Elkashef SM
PROVIDER: S-EPMC5017143 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Elkashef Sara M SM Allison Simon J SJ Sadiq Maria M Basheer Haneen A HA Ribeiro Morais Goreti G Loadman Paul M PM Pors Klaus K Falconer Robert A RA
Scientific reports 20160909
Polysialic acid (polySia) is a unique carbohydrate polymer expressed on the surface of NCAM (neuronal cell adhesion molecule) in a number of cancers where it modulates cell-cell and cell-matrix adhesion, migration, invasion and metastasis and is strongly associated with poor clinical prognosis. We have carried out the first investigation into the effect of polySia expression on the behaviour of cancer cells in hypoxia, a key source of chemoresistance in tumours. The role of polysialylation and a ...[more]