Ontology highlight
ABSTRACT:
SUBMITTER: He Q
PROVIDER: S-EPMC5017585 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
He Quan Q Shumate Christie K CK White Mark A MA Molineux Ian J IJ Yin Y Whitney YW
Mitochondrion 20130830 6
Pol γ, the only DNA polymerase found in human mitochondria, functions in both mtDNA repair and replication. During mtDNA base-excision repair, gaps are created after damaged base excision. Here we show that Pol γ efficiently gap-fills except when the gap is only a single nucleotide. Although wild-type Pol γ has very limited ability for strand displacement DNA synthesis, exo(-) (3'-5' exonuclease-deficient) Pol γ has significantly high activity and rapidly unwinds downstream DNA, synthesizing DNA ...[more]