Ontology highlight
ABSTRACT:
SUBMITTER: Napolitano A
PROVIDER: S-EPMC5018040 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Napolitano A A Pellegrini L L Dey A A Larson D D Tanji M M Flores E G EG Kendrick B B Lapid D D Powers A A Kanodia S S Pastorino S S Pass H I HI Dixit V V Yang H H Carbone M M
Oncogene 20150629 15
Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally exposed to asbestos. We hypothesized that germline BAP1 mutations might influence the asbestos-induced inflammatory response that is linked to asbestos carcinogenesis, thereby increasing ...[more]