Ontology highlight
ABSTRACT:
SUBMITTER: Lazarou M
PROVIDER: S-EPMC5018156 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Lazarou Michael M Sliter Danielle A DA Kane Lesley A LA Sarraf Shireen A SA Wang Chunxin C Burman Jonathon L JL Sideris Dionisia P DP Fogel Adam I AI Youle Richard J RJ
Nature 20150812 7565
Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains on mitochondrial outer membrane proteins, where they act to recruit autophagy receptors. Using genome editing to knockout five autophagy receptors in HeLa cells, here we show that two receptors previously linked to xenophagy, NDP52 and optineurin, ...[more]