Ontology highlight
ABSTRACT:
SUBMITTER: Briney B
PROVIDER: S-EPMC5018249 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Briney Bryan B Sok Devin D Jardine Joseph G JG Kulp Daniel W DW Skog Patrick P Menis Sergey S Jacak Ronald R Kalyuzhniy Oleksandr O de Val Natalia N Sesterhenn Fabian F Le Khoa M KM Ramos Alejandra A Jones Meaghan M Saye-Francisco Karen L KL Blane Tanya R TR Spencer Skye S Georgeson Erik E Hu Xiaozhen X Ozorowski Gabriel G Adachi Yumiko Y Kubitz Michael M Sarkar Anita A Wilson Ian A IA Ward Andrew B AB Nemazee David D Burton Dennis R DR Schief William R WR
Cell 20160901 6
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiate a bnAb response in animal models, but recall and maturation toward bnAb development has not been shown. Here, we report the development of boosting immunogens designed to guide th ...[more]