Dataset Information

Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

ABSTRACT:

Background

A growing body of evidence supports a beneficial role for vitamin K in brain and cognition, notably in studies where animals are rendered vitamin K deficient by warfarin, a potent vitamin K antagonist (VKA). Given VKAs are commonly used oral anticoagulants in older persons, we investigated the relationship between VKA therapy and cognitive performances over 10 years in participants of the Three-City study.

Methods

The Three-City cohort included 7,133 nondemented community dwellers, aged 65 years or older at baseline. Exposures to VKAs and platelet aggregation inhibitors, another antithrombotic agent, were determined at baseline. Participants underwent cognitive assessment at baseline and every 2 years over 10 years. Associations were analyzed with mixed linear models adjusting for many covariates including VKA and platelet aggregation inhibitor indications.

Results

About 239 (3.4%) and 1,192 (16.7%) of the participants were treated with VKAs and platelet aggregation inhibitors at baseline, respectively. VKA treatment was significantly associated with worse performances on Benton Visual Retention Test assessing visual memory (adjusted mean difference -0.29; p = .02 in multivariate models) and Isaacs Set Test assessing verbal fluency (adjusted mean difference -1.37; p = .0009) at baseline. Treatment with VKAs was not associated with global cognitive functioning on the Mini Mental State Examination, neither with rate of subsequent decline in scores on all three cognitive tests. No associations were found between platelet aggregation inhibitors and cognitive performances or rate of decline.

Conclusion

These findings do not indicate a long-term detrimental effect of VKAs on cognition, but the risk-benefit balance of VKA treatment still deserves further research.

SUBMITTER: Ferland G

PROVIDER: S-EPMC5018559 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

Ferland Guylaine G Feart Catherine C Presse Nancy N Lorrain Simon S Bazin Fabienne F Helmer Catherine C Berr Claudine C Annweiler Cedric C Rouaud Olivier O Dartigues Jean-François JF Fourrier-Reglat Annie A Barberger-Gateau Pascale P

The journals of gerontology. Series A, Biological sciences and medical sciences 20151117 10

<h4>Background</h4>A growing body of evidence supports a beneficial role for vitamin K in brain and cognition, notably in studies where animals are rendered vitamin K deficient by warfarin, a potent vitamin K antagonist (VKA). Given VKAs are commonly used oral anticoagulants in older persons, we investigated the relationship between VKA therapy and cognitive performances over 10 years in participants of the Three-City study.<h4>Methods</h4>The Three-City cohort included 7,133 nondemented communi ...[more]

PMID: 26576841

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Dataset Information

Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

Background

Methods

Results

Conclusion

Publications

Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study.

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