IP3 receptors: Take four IP3 to open.
Ontology highlight
ABSTRACT:
SUBMITTER: Taylor CW
PROVIDER: S-EPMC5019202 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
IP3 receptors: Take four IP3 to open.
Taylor Colin W CW Konieczny Vera V
Science signaling 20160405 422
Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells. ...[more]
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