Ontology highlight
ABSTRACT:
SUBMITTER: Rogawski DS
PROVIDER: S-EPMC5020427 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Rogawski David S DS Grembecka Jolanta J Cierpicki Tomasz T
Future medicinal chemistry 20160822 13
Methylation at histone 3, lysine 36 (H3K36) is a conserved epigenetic mark regulating gene transcription, alternative splicing and DNA repair. Genes encoding H3K36 methyltransferases (KMTases) are commonly overexpressed, mutated or involved in chromosomal translocations in cancer. Molecular biology studies have demonstrated that H3K36 KMTases regulate oncogenic transcriptional programs. Structural studies of the catalytic SET domain of H3K36 KMTases have revealed intriguing opportunities for des ...[more]