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Chronic Moderate Alcohol Intakes Accelerate SR-B1 Mediated Reverse Cholesterol Transport.


ABSTRACT: Cholesterol is essential for all animal life. However, a high level of cholesterol in the body is strongly associated with the progression of various severe diseases. In our study, the potential involvement of alcohol in the regulation of high density lipoprotein (HDL) receptor scavenger receptor class B and type I (SR-B1)-mediated reverse cholesterol transport was investigated. We separated male C57BL/6 mice into four diets: control, alcohol, Control?+?HC and alcohol?+?HC. The SR-B1 level and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate- high- density lipoprotein (DiI-HDL) uptake were also measured in AML12 cells and HL7702 cells treated with alcohol. The control?+?HC diet led to increased hepatic triglyceride and cholesterol levels while alcohol?+?HC led no significant change. Compared with that of the control group, the SR-B1 mRNA level was elevated by 27.1% (P?

SUBMITTER: Li M 

PROVIDER: S-EPMC5020497 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Chronic Moderate Alcohol Intakes Accelerate SR-B1 Mediated Reverse Cholesterol Transport.

Li Menghua M   Diao Yan Y   Liu Ying Y   Huang Hui H   Li Yanze Y   Tan Peizhu P   Liang Huan H   He Qi Q   Nie Junhui J   Dong Xingli X   Wang Yang Y   Zhou Lingyun L   Gao Xu X  

Scientific reports 20160913


Cholesterol is essential for all animal life. However, a high level of cholesterol in the body is strongly associated with the progression of various severe diseases. In our study, the potential involvement of alcohol in the regulation of high density lipoprotein (HDL) receptor scavenger receptor class B and type I (SR-B1)-mediated reverse cholesterol transport was investigated. We separated male C57BL/6 mice into four diets: control, alcohol, Control + HC and alcohol + HC. The SR-B1 level and 1  ...[more]

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