Ontology highlight
ABSTRACT:
SUBMITTER: Ah-Koon L
PROVIDER: S-EPMC5020624 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ah-Koon Laurent L Lesage Denis D Lemadre Elodie E Souissi Inès I Fagard Remi R Varin-Blank Nadine N Fabre Emmanuelle E EE Schischmanoff Olivier O
Journal of cellular and molecular medicine 20160727 10
The SN 1 alkylating agents activate the mismatch repair system leading to delayed G2 /M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti-proliferative and pro-apoptotic transcription factor is known to potentiate p53 and to affect DNA-damage cellular response. We studied whether STAT1 may modulate cell fate following activation of the mismatch repair system upon exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Using STAT1-profic ...[more]