Ontology highlight
ABSTRACT:
SUBMITTER: Mugwanya K
PROVIDER: S-EPMC5021224 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Mugwanya Kenneth K Baeten Jared J Celum Connie C Donnell Deborah D Nickolas Thomas T Mugo Nelly N Branch Andrea A Tappero Jordan J Kiarie James J Ronald Allan A Yin Michael M Wyatt Christina C
The Journal of infectious diseases 20160329 7
<h4>Objective</h4>Tenofovir disoproxil fumarate (TDF) is associated with proximal tubular dysfunction (tubulopathy) when used in the treatment of human immunodeficiency virus (HIV) infection. We evaluated whether TDF causes tubulopathy when used as HIV preexposure prophylaxis (PrEP) and whether tubulopathy predicts clinically relevant decline (≥25%) in the estimated glomerular filtration rate (eGFR).<h4>Methods</h4>A subgroup analysis of the Partners PrEP Study, a randomized, placebo-controlled ...[more]