Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Hur V
PROVIDER: S-EPMC5021319 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ben-Hur Vered V Denichenko Polina P Siegfried Zahava Z Maimon Avi A Krainer Adrian A Davidson Ben B Karni Rotem R
Cell reports 20121227 1
Ribosomal S6 kinase 1 (S6K1) is a major mTOR downstream signaling molecule that regulates cell size and translation efficiency. Here, we report that short isoforms of S6K1 are overproduced in breast cancer cell lines and tumors. Overexpression of S6K1 short isoforms induces transformation of human breast epithelial cells. The long S6K1 variant (Iso-1) induced opposite effects. It inhibits Ras-induced transformation and tumor formation, while its knockdown or knockout induces transformation, sugg ...[more]