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Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

ABSTRACT: Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.

SUBMITTER: Greene M

PROVIDER: S-EPMC5021350 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

Greene Maxwell M Lai Yongjie Y Pajcini Kostandin K Bailis Will W Pear Warren S WS Lancaster Eric E

PloS one 20160913 9

Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown. ...[more]

PMID: 27622512

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Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.

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