Ontology highlight
ABSTRACT:
SUBMITTER: Klein JD
PROVIDER: S-EPMC5021354 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Klein Jonathon D JD Qu Chunxu C Yang Xiaoyang X Fan Yiping Y Tang Chunlao C Peng Jamy C JC
PLoS genetics 20160913 9
Drosophila melanogaster Piwi functions within the germline stem cells (GSCs) and the somatic niche to regulate GSC self-renewal and differentiation. How Piwi influences GSCs is largely unknown. We uncovered a genetic interaction between Piwi and c-Fos in the somatic niche that influences GSCs. c-Fos is a proto-oncogene that influences many cell and developmental processes. In wild-type ovarian cells, c-Fos is post-transcriptionally repressed by Piwi, which destabilized the c-Fos mRNA by promotin ...[more]