Ontology highlight
ABSTRACT:
SUBMITTER: Townsley S
PROVIDER: S-EPMC5021413 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Journal of virology 20160912 19
<h4>Unlabelled</h4>Poxvirus prime-protein boost used in the RV144 trial remains the only immunization strategy shown to elicit a modest level of protection against HIV-1 acquisition in humans. Although neutralizing antibodies (NAb) were generated, they were against sensitive viruses, not the more resistant "tier 2" isolates that dominate circulating strains. Instead, risk reduction correlated with antibodies recognizing epitopes in the V1/V2 region of HIV-1 envelope glycoprotein (Env). Here, we ...[more]