Ontology highlight
ABSTRACT:
SUBMITTER: Schneider VA
PROVIDER: S-EPMC5021996 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Schneider Viktoria A F VA Coorens Maarten M Ordonez Soledad R SR Tjeerdsma-van Bokhoven Johanna L M JL Posthuma George G van Dijk Albert A Haagsman Henk P HP Veldhuizen Edwin J A EJ
Scientific reports 20160914
Host defence peptides (HDPs) have the potential to become alternatives to conventional antibiotics in human and veterinary medicine. The HDP chicken cathelicidin-2 (CATH-2) has immunomodulatory and direct killing activities at micromolar concentrations. In this study the mechanism of action of CATH-2 against Escherichia coli (E. coli) was investigated in great detail using a unique combination of imaging and biophysical techniques. Live-imaging with confocal fluorescence microscopy demonstrated ...[more]