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New Oral Therapies for Psoriasis: A Comprehensive Review.


ABSTRACT: Conventional oral therapies for psoriasis, including methotrexate, cyclosporine, and acitretin, have generally unfavorable safety profiles and are not ideal for long-standing use. Thus, new oral therapies are necessary for patients with more moderate disease, patients who prefer oral treatments to injectable biologies, and patients who failed conventional therapies. The authors review here the clinical and safety evidence of phosphodiesterase 4 inhibitor, apremilast, janus kinase inhibitors, including tofacitinib, and fumarie acid esters as additional options in oral psoriasis therapy.

SUBMITTER: Goldenberg G 

PROVIDER: S-EPMC5022993 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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New Oral Therapies for Psoriasis: A Comprehensive Review.

Goldenberg Gary G   Lanoue Julien J   Dong Joanna J  

The Journal of clinical and aesthetic dermatology 20160801 8


Conventional oral therapies for psoriasis, including methotrexate, cyclosporine, and acitretin, have generally unfavorable safety profiles and are not ideal for long-standing use. Thus, new oral therapies are necessary for patients with more moderate disease, patients who prefer oral treatments to injectable biologies, and patients who failed conventional therapies. The authors review here the clinical and safety evidence of phosphodiesterase 4 inhibitor, apremilast, janus kinase inhibitors, inc  ...[more]

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