Ontology highlight
ABSTRACT:
SUBMITTER: Nechipurenko IV
PROVIDER: S-EPMC5023068 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Developmental cell 20160901 5
Primary cilia are ubiquitous sensory organelles that mediate diverse signaling pathways. Cilia position on the cell surface is determined by the location of the basal body (BB) that templates the cilium. The mechanisms that regulate BB positioning in the context of ciliogenesis are largely unknown. Here we show that the conserved signaling and scaffolding protein Girdin localizes to the proximal regions of centrioles and regulates BB positioning and ciliogenesis in Caenorhabditis elegans sensory ...[more]