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Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis.


ABSTRACT:

Objective

To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.

Design

Retrospective cohort study.

Setting

University hospital, tertiary care center.

Patients

Women with recurrent miscarriage (78 explained, 66 idiopathic).

Intervention(s)

None.

Main outcome measures(s)

Anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and age.

Results

Anti-Mullerian hormone and estradiol were significantly lower in women with idiopathic recurrent miscarriage (median 1.2 ng/ml, IQR 0.6-2.1, and median 36.5 pg/ml, IQR 25.8-47.3, respectively) than in women with explained recurrent miscarriage (median 2.0 ng/ml, IQR 1.1-2.7, and median 42.5 pg/ml, IQR 32.8-59.8, respectively; p<0.05). Optimized cut-off values for the prediction of idiopathic recurrent miscarriage were <39.5 pg/ml for estradiol (sensitivity: 63.3%, 95% CI: 50.9-75.1; specificity: 56.4%, 95% CI: 44.7-67.6) and <1.90 ng/ml for anti-Mullerian hormone (sensitivity: 72.7%, 95% CI: 60.4-83.0; specificity: 52.6%, 95% CI: 40.9-64.0).

Conclusion

Idiopathic recurrent miscarriage was associated with lower basal estradiol and anti-Mullerian hormone levels compared to explained recurrent miscarriage.

SUBMITTER: Pils S 

PROVIDER: S-EPMC5023100 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Decreased Ovarian Reserve Predicts Inexplicability of Recurrent Miscarriage? A Retrospective Analysis.

Pils Sophie S   Promberger Regina R   Springer Stephanie S   Joura Elmar E   Ott Johannes J  

PloS one 20160914 9


<h4>Objective</h4>To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>University hospital, tertiary care center.<h4>Patients</h4>Women with recurrent miscarriage (78 explained, 66 idiopathic).<h4>Intervention(s)</h4>None.<h4>Main outcome measures(s)</h4>Anti-Mulleri  ...[more]

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