Ontology highlight
ABSTRACT:
SUBMITTER: Hombach AA
PROVIDER: S-EPMC5023391 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Hombach Andreas A AA Görgens André A Chmielewski Markus M Murke Florian F Kimpel Janine J Giebel Bernd B Abken Hinrich H
Molecular therapy : the journal of the American Society of Gene Therapy 20160426 8
Recent clinical trials with chimeric antigen receptor (CAR) redirected T cells targeting CD19 revealed particular efficacy in the treatment of leukemia/lymphoma, however, were accompanied by a lasting depletion of healthy B cells. We here explored CD30 as an alternative target, which is validated in lymphoma therapy and expressed by a broad variety of Hodgkin's and non-Hodgkin's lymphomas. As a safty concern, however, CD30 is also expressed by lymphocytes and hematopoietic stem and progenitor ce ...[more]