Ontology highlight
ABSTRACT:
SUBMITTER: Sassi C
PROVIDER: S-EPMC5024078 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sassi Celeste C Nalls Michael A MA Ridge Perry G PG Gibbs Jesse R JR Ding Jinhui J Lupton Michelle K MK Troakes Claire C Lunnon Katie K Al-Sarraj Safa S Brown Kristelle S KS Medway Christopher C Clement Naomi N Lord Jenny J Turton James J Bras Jose J Almeida Maria R MR Holstege Henne H Louwersheimer Eva E van der Flier Wiesje M WM Scheltens Philip P Van Swieten John C JC Santana Isabel I Oliveira Catarina C Morgan Kevin K Powell John F JF Kauwe John S JS Cruchaga Carlos C Goate Alison M AM Singleton Andrew B AB Guerreiro Rita R Hardy John J
Neurobiology of aging 20160420
Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution of these loci to AD pathogenesis, their genetic architecture has not been extensively investigated, leaving the possibility that low frequency and rare coding variants may also occ ...[more]