Ontology highlight
ABSTRACT:
SUBMITTER: Foldy C
PROVIDER: S-EPMC5024636 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Földy Csaba C Darmanis Spyros S Aoto Jason J Malenka Robert C RC Quake Stephen R SR Südhof Thomas C TC
Proceedings of the National Academy of Sciences of the United States of America 20160816 35
In brain, signaling mediated by cell adhesion molecules defines the identity and functional properties of synapses. The specificity of presynaptic and postsynaptic interactions that is presumably mediated by cell adhesion molecules suggests that there exists a logic that could explain neuronal connectivity at the molecular level. Despite its importance, however, the nature of such logic is poorly understood, and even basic parameters, such as the number, identity, and single-cell expression prof ...[more]