Ontology highlight
ABSTRACT:
SUBMITTER: Sato M
PROVIDER: S-EPMC5024646 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sato Makoto M Yasugi Tetsuo T Minami Yoshiaki Y Miura Takashi T Nagayama Masaharu M
Proceedings of the National Academy of Sciences of the United States of America 20160817 35
Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition durin ...[more]