Predictive Factors and Value of ypN+ after Neoadjuvant Chemotherapy in Clinically Lymph Node-Negative Breast Cancer.

ABSTRACT:

Background

Pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) has been regarded as a surrogate endpoint for disease-free survival (DFS) and overall survival (OS) of patients with breast cancer. No consensus regarding the definition of pCR has been established; there are several definitions according to a variety of classifications. Eradication of cancer cells in both breast and lymph nodes has been better associated with improved prognosis than in the breast alone. Even in patients diagnosed as having clinically node-negative cancer before NAC, postoperative pathological examination often shows axillary lymph node metastases.

Patients and methods

Of the 771 patients with breast cancer who underwent NAC in the Cancer Institute Hospital between January 20

SUBMITTER: Fukada I 

PROVIDER: S-EPMC5025211 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature