Ontology highlight
ABSTRACT:
SUBMITTER: Chung LK
PROVIDER: S-EPMC5025386 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Chung Lawton K LK Park Yong Hwan YH Zheng Yueting Y Brodsky Igor E IE Hearing Patrick P Kastner Daniel L DL Chae Jae Jin JJ Bliska James B JB
Cell host & microbe 20160825 3
Pathogenic Yersinia, including Y. pestis, the agent of plague in humans, and Y. pseudotuberculosis, the related enteric pathogen, deliver virulence effectors into host cells via a prototypical type III secretion system to promote pathogenesis. These effectors, termed Yersinia outer proteins (Yops), modulate multiple host signaling responses. Studies in Y. pestis and Y. pseudotuberculosis have shown that YopM suppresses infection-induced inflammasome activation; however, the underlying molecular ...[more]