Sensitivity to Change of Patient-Preference Measures for Pain in Patients With Knee Osteoarthritis: Data From Two Trials.

ABSTRACT:

Objective

In osteoarthritis (OA) clinical trials, a pain measure that is most sensitive to change is considered optimal. We compared sensitivity to change of patient-reported pain outcomes, including a patient-preference measure (where the patient nominates an activity that aggravates their pain).

Methods

We used data from 2 trials of patients with confirmed (American College of Rheumatology criteria) knee OA: a trial of brace treatment for patellofemoral OA, and a trial of intraarticular steroids in knee OA. Both trials reported an improvement in pain following treatment. Participants rated pain on a 100-mm visual analog scale (VAS), in the activity that caused them the most knee pain (VASNA ), as well as completing questions on overall knee pain and the Knee Injury and Ost

SUBMITTER: Parkes MJ 

PROVIDER: S-EPMC5025729 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature