Ontology highlight
ABSTRACT:
SUBMITTER: Verbeke L
PROVIDER: S-EPMC5025787 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Verbeke Len L Mannaerts Inge I Schierwagen Robert R Govaere Olivier O Klein Sabine S Vander Elst Ingrid I Windmolders Petra P Farre Ricard R Wenes Mathias M Mazzone Massimiliano M Nevens Frederik F van Grunsven Leo A LA Trebicka Jonel J Laleman Wim W
Scientific reports 20160916
Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The Farnesoid-X receptor (FXR) antagonizes inflammation through NF-κB inhibition. We investigated preventive and therapeutic effects of FXR agonist obeticholic acid (OCA) on hepatic inflammation and fibrosis in toxic cirrhotic rats. Cirrhosis was induced by thioacetamide (TAA) intoxication. OCA was given during or after intoxication with vehicle-treated rats as controls. At sacrifice, fibrosis, hemodynamic and ...[more]