Ontology highlight
ABSTRACT:
SUBMITTER: Rai A
PROVIDER: S-EPMC5026484 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Rai Amrita A Oprisko Anastasia A Campos Jeremy J Fu Yangxue Y Friese Timon T Itzen Aymelt A Goody Roger S RS Gazdag Emerich Mihai EM Müller Matthias P MP
eLife 20160823
In their active GTP-bound form, Rab proteins interact with proteins termed effector molecules. In this study, we have thoroughly characterized a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. Within our study, we show that these effectors display a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and that some of the effector domains can bind two Rab proteins via separate binding sites. Structural analysis allo ...[more]