Ontology highlight
ABSTRACT:
SUBMITTER: Songia P
PROVIDER: S-EPMC5026583 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Songia Paola P Branchetti Emanuela E Parolari Alessandro A Myasoedova Veronika V Ferrari Giovanni G Alamanni Francesco F Tremoli Elena E Poggio Paolo P
Journal of molecular and cellular cardiology 20160623
<h4>Aims</h4>Mitral valve prolapse (MVP) has a prevalence of 3% in the general population, affecting >176 million people worldwide. Despite this, little is known about the molecular and cellular mechanisms involved in the progression of MVP and surgical intervention is the only available option. In this study we investigated the role of osteoprotegerin (OPG) during endothelial to mesenchymal transition (EndMT) in MVP.<h4>Methods and results</h4>VECs and VICs were isolated from posterior mitral v ...[more]