Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53.
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ABSTRACT:
SUBMITTER: Kuan MI
PROVIDER: S-EPMC5026618 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53.
Kuan Man I MI O'Dowd John M JM Chughtai Kamila K Hayman Ian I Brown Celeste J CJ Fortunato Elizabeth A EA
Virology 20160805
Human Cytomegalovirus (HCMV) infection is compromised in cells lacking p53, a transcription factor that mediates cellular stress responses. In this study we have investigated compromised functional virion production in cells with p53 knocked out (p53KOs). Infectious center assays found most p53KOs released functional virions. Analysis of electron micrographs revealed modestly decreased capsid production in infected p53KOs compared to wt. Substantially fewer p53KOs displayed HCMV-induced infoldin ...[more]
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