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Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.


ABSTRACT: Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy.One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis.Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients.

SUBMITTER: Lee CH 

PROVIDER: S-EPMC5027188 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.

Lee Cheng-Hsueh CH   Pao Jiunn-Bey JB   Lu Te-Ling TL   Lee Hong-Zin HZ   Lee Yung-Chin YC   Liu Chia-Chu CC   Huang Chao-Yuan CY   Lin Victor C VC   Yu Chia-Cheng CC   Yin Hsin-Ling HL   Huang Shu-Pin SP   Bao Bo-Ying BY  

International journal of medical sciences 20160811 9


<h4>Unlabelled</h4>Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.<h4>Methods</h4>We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations a  ...[more]

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