Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC5027247 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Li Faxiang F Xie Xingqiao X Wang Yingli Y Liu Jianping J Cheng Xiaofang X Guo Yujiao Y Gong Yukang Y Hu Shichen S Pan Lifeng L
Nature communications 20160913
Optineurin is an important autophagy receptor involved in several selective autophagy processes, during which its function is regulated by TBK1. Mutations of optineurin and TBK1 are both associated with neurodegenerative diseases. However, the mechanistic basis underlying the specific interaction between optineurin and TBK1 is still elusive. Here we determine the crystal structures of optineurin/TBK1 complex and the related NAP1/TBK1 complex, uncovering the detailed molecular mechanism governing ...[more]