Ontology highlight
ABSTRACT:
SUBMITTER: Xiao H
PROVIDER: S-EPMC5027407 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Xiao Han H Woods Elliot C EC Vukojicic Petar P Bertozzi Carolyn R CR
Proceedings of the National Academy of Sciences of the United States of America 20160822 37
Cell surface sialosides constitute a central axis of immune modulation that is exploited by tumors to evade both innate and adaptive immune destruction. Therapeutic strategies that target tumor-associated sialosides may therefore potentiate antitumor immunity. Here, we report the development of antibody-sialidase conjugates that enhance tumor cell susceptibility to antibody-dependent cell-mediated cytotoxicity (ADCC) by selective desialylation of the tumor cell glycocalyx. We chemically fused a ...[more]