Ontology highlight
ABSTRACT:
SUBMITTER: Margara LM
PROVIDER: S-EPMC5027486 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Margara Lucía M LM Fernández Marisa M MM Malchiodi Emilio L EL Argaraña Carlos E CE Monti Mariela R MR
Nucleic acids research 20160601 16
Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in bacteria and lead to human disease. Effective activity of these enzymes requires association with ring-shaped processivity factors, which dictate their access to sites of DNA synthesis. Here, we show for the first time that the mismatch repair protein MutS plays a role in regulat ...[more]