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Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa.

ABSTRACT: We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 and CV79). This subgroup is one of the major determinants of HTLV-1 infections in North and West Africa, and recombinant strains involving this subgroup have been recently demonstrated. The CV21 and CV79 strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes, comparative analyses including HTLV-1 subtypes and subgroups revealed HTLV-1aD signatures in the envelope, pol, and pX regions. These genomes provide original information that will contribute to further studies on HTLV-1a epidemiology and evolution.

SUBMITTER: Zanella L

PROVIDER: S-EPMC5027869 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Genome-wide analyses of HTLV-1aD strains from Cape Verde, Africa.

Zanella Louise L Pina-Araujo I Isabel de Id Morgado Mariza G MG Vicente Ana Carolina AC

Memorias do Instituto Oswaldo Cruz 20160901 9

We characterised and reported the first full-length genomes of Human T-cell Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 and CV79). This subgroup is one of the major determinants of HTLV-1 infections in North and West Africa, and recombinant strains involving this subgroup have been recently demonstrated. The CV21 and CV79 strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes, comparative analyses including HTLV-1 subtypes and subgroups revealed HTLV-1aD signatures in t ...[more]

PMID: 27653363

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