Dataset Information

Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.

ABSTRACT:

Background and aim

Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup.

Methods

Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data on symptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected.

Results

The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient- and general practitioner-based questionnaires.

Conclusion

The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platform for future research studies in childhood cancer patients.?.

SUBMITTER: Feijen EA

PROVIDER: S-EPMC5028033 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.

Feijen Elizabeth A M EA Font-Gonzalez Anna A van Dalen Elvira C EC van der Pal Helena J H HJ Reulen Raoul C RC Winter David L DL Kuehni Claudia E CE Haupt Riccardo R Alessi Daniela D Byrne Julianne J Bardi Edit E Jakab Zsuzsanna Z Grabow Desiree D Garwicz Stanislaw S Jankovic Momcilo M Levitt Gill A GA Skinner Roderick R Zadravec Zaletel Lorna L Hjorth Lars L Tissing Wim J E WJ de Vathaire Florent F Hawkins Mike M MM Kremer Leontien C M LC

PloS one 20160919 9

<h4>Background and aim</h4>Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup.<h4>Methods</h4>Eight data providers in Europe participating in PanCareSurFup identif ...[more]

PMID: 27643694

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Dataset Information

Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.

Background and aim

Methods

Results

Conclusion

Publications

Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup.

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