Unknown

Dataset Information

0

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.


ABSTRACT: Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (vRGs) and promoted generation of self-renewing basal progenitors with typical morphology of outer radial glia (oRG), which are most abundant in primates. Furthermore, down-regulation of TBC1D3 in cultured human brain slices decreased generation of oRGs. Interestingly, localized oRG proliferation resulting from either in utero electroporation or transgenic expression of TBC1D3, was often found to underlie cortical regions exhibiting folding. Thus, we have identified a hominoid gene that is required for oRG generation in regulating the cortical expansion and folding.

SUBMITTER: Ju XC 

PROVIDER: S-EPMC5028191 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.

Ju Xiang-Chun XC   Hou Qiong-Qiong QQ   Sheng Ai-Li AL   Wu Kong-Yan KY   Zhou Yang Y   Zhou Yang Y   Jin Ying Y   Wen Tieqiao T   Yang Zhengang Z   Wang Xiaoqun X   Luo Zhen-Ge ZG  

eLife 20160809


Cortical expansion and folding are often linked to the evolution of higher intelligence, but molecular and cellular mechanisms underlying cortical folding remain poorly understood. The hominoid-specific gene TBC1D3 undergoes segmental duplications during hominoid evolution, but its role in brain development has not been explored. Here, we found that expression of TBC1D3 in ventricular cortical progenitors of mice via in utero electroporation caused delamination of ventricular radial glia cells (  ...[more]

Similar Datasets

2021-02-08 | GSE136283 | GEO
2021-02-08 | GSE136282 | GEO
2021-02-08 | GSE136281 | GEO
| S-EPMC7810367 | biostudies-literature
| S-SCDT-EMBOR-2021-53602V1 | biostudies-other
2014-05-01 | E-GEOD-45451 | biostudies-arrayexpress
| S-EPMC2442359 | biostudies-literature
2014-05-01 | GSE45451 | GEO
| PRJNA561829 | ENA
| S-EPMC2746711 | biostudies-literature