Ontology highlight
ABSTRACT:
SUBMITTER: Polaski JT
PROVIDER: S-EPMC5028336 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cell reports 20160421 5
Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between metabolite binding and gene regulation by the downstream regulatory domain. Using a combination of cell-based, biochemical, and biophysical techniques, we reveal the specific RNA archit ...[more]